Thursday, December 11, 2008

profile 12: michael krische



so i realize i have a thing for organikers. this one was nominated by kristy before, and well, i can see why. he has that smug almost cocky grin, which is well, quite sexy actually. i've been looking through his work, and well it's an impressive body of work. he's a welch professor of chemistry at the university of texas at austin, and has won numerous awards. he does green chemistry, and considering i like the environment, that adds sexyness points i think. he worked for barry trost from stanford, so his academic 'family' is quite impressive. he probably has the same work ethic too. regan jones, one of the featured graduate students from grad set 1, way back in 2006 is in his group, so i dont know why i didnt feature prof. krische before. either way, enjoy. i think he's hot ;)

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Natural Product Synthesis, Catalytic Reaction Development, Organometallic Chemistry and Self-Assembly

Our research focuses on catalytic reaction development with attendant applications in natural product synthesis. A central theme involves the identification of new reactivity patterns, the evolution of related catalytic processes and, ultimately, the development of new synthetic strategies. Specific areas of research include: (a) hydrogen-mediated C-C bond formation, (b) nucleophilic catalysis via phosphine conjugate addition, (c) catalytic tandem conjugate addition-electrophilic trapping, and (d) metal-catalyzed [2+2]cycloaddition.


H2-Mediated C-C Bond Formation: The formation of carbon-carbon (C-C) bonds is of fundamental significance. Research in the Krische laboratory demonstrates that C-C bond formation may be achieved under the conditions of catalytic hydrogenation and transfer hydrogenation. These studies represent the first systematic efforts to exploit hydrogenation in C-C couplings beyond hydroformylation and define a departure from the use of preformed organometallic reagents in carbonyl addition.


The Krische group reports that diverse π-unsaturated reactants reductively couple to carbonyl compounds and imines under hydrogenation conditions, thereby providing a byproduct-free alternative to stoichiometrically preformed organometallic reagents in a range of classical C=X (X = O, NR) addition processes. In such transformations, one simply hydrogenates two molecules in the presence of one another to form a single more complex product. This work evokes the question of whether all processes employing stoichiometric metallic reagents can be conducted catalytically under hydrogenative conditions.


More recently, by exploiting alcohols as both hydrogen donors and aldehyde precursors, byproduct-free carbonyl addition is achieved from the alcohol oxidation level. Such alcohol-unsaturate C-C couplings circumvent the redox manipulations often required to convert alcohols to aldehydes, and again bypass the barriers imposed by the use of stoichiometrically preformed organometallics. As chemical industry shifts from petrochemicals to renewable feedstocks, such direct byproduct-free couplings of alcohols are anticipated to find broad use.
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he's a natural products chemist too! oh phil, i think someone else is taking your spot, but who am i kidding..you're the natty products chemist for me. krische is close though ;)

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